Hi,
#> python -V
Python 3.9.0
#> pip3 install virtualenv
#> mkdir ~/venv_arduino
#> cd $_
#> virtualenv .
#> source ./bin/activate
#> vim ~/Library/Arduino15/packages/esp32/hardware/esp32/1.0.4/tools/esptool.py
Change:
#!/usr/bin/env python
to
#!/usr/bin/env python3

#> pip install ...