Hello ESP_Sprite,

Thank you for pointing out that 'C14' (in the aforementioned schematic) should be read as: "Don't place".
(I probably missed that because I was unfamiliar with the usage of "NC" for "NOSTUFF", teaches me to be more observant.)

It would seem I indeed have to "jump in the rabbit ...

Hello ESP_Sprite, thank you for taking the time to answer my question.

However, I am still confused.
Maybe because I was too concise?
Then I will try to be more verbose this time.

In our project I am using an ESP32-wrover-e module that I would like to program over USB-C(2.0) from any computer ...

The use of printf() in interrupt routines is something best avoided.
(since printf() may be a macro, a function, or something else that disables interrupts)

If you want to "printf()" something, then sprintf() to a (global) buffer first, and then printf the buffer somewhere outside of the interrupt ...

Hello,

Having studied the (reference) designs of the CP2102N based ESP32-devkits boards.
(with the transistors used for DTR, EN, RTS and IO0.)

ESP32_DEVKITS_20190621.pdf
was one of my sources, but a multiple of others share the same idea.
(or just copied and pasted it)

I'm confused as to how ...