Thanks "lbernstone" for your feedback.
Sorry, but I'm confused. When the reset occurs, the PC application is connected to the ESP32 through the native USB. So, the RTS is not driven from the app because there are only the D+ and D- signals in the USB. Is it the ESP32 by itself that drives the RTS ...

The Arduino serial monitor does not generate the device reboot. Additionally, the Teraterm app does not trigger a device restart when it opens the COM port.
However, in many other Windows apps, particularly customer apps, a device reboot is triggered.
The native USB connection has only the D+ and D ...

I have two projects: both use the ESP32S3, and both utilise the native USB as the virtual serial communication with specific desktop applications.
One project is developed in IDF, and the other in Arduino.
In both projects, we have set up the native USB in CDC mode .
In IDF , using the sdkconfig ...