(Thanks for your responese)

Do you have schematics and PCB images we can take a look at?

Yes, I will send them later, they are not on the Computer, that I am using to write this...
The Peripheral Schematic (https://www.mouser.de/datasheet/2/891/esp32_s3_mini_1_mini_1u_datasheet_en-2997643.pdf ...

Hello!
I have an ESP32-S3 chip (just the chip, not the whole board). I have it on my own PCB, the only Data Lines I have are D+ and D-.
I found out to flash a completely new chip in the Arduino IDE you need to first flash a bootloader, which enables USB CDC, with UART.
So I took a USB to UART ...